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Study finds link between metabolic health and menopause

The research, led by personalized nutrition company ZOE and scientists from King’s College London, Harvard TH Chan School of Public Health and Massachusetts General Hospital, examined the effects of menopause on day-to-day metabolism and discovered that it was possible to reduce weight gain. during this time.

Dr Sarah Berry, lead author of the study, Senior Nutrition Scientist at ZOE and Associate Professor of Nutritional Science in the Department of Nutritional Science at King’s College London, says: “Menopause has historically been vastly understudied, and women have been underrepresented in health research, especially regarding diet and health.

“Our research shows that menopause is a time of major metabolic upheavals, which can have a significant impact on long-term health. These findings will help us provide simple yet more personalized nutrition and health advice with greater effectiveness in reducing the health burden of menopause.

Blood sugar levels

The study showed key differences in blood sugar levels and inflammation in pre- and post-menopausal women after eating.

However, the detrimental impact of menopause on blood sugar control, which poses risks for cardiovascular disease and type 2 diabetes, was found in both groups of women – highlighting that reduced blood sugar control n It wasn’t just something that happened when women got older.

Research also found that increased body fat and inflammation during menopause was controlled, in part, by the microbiome and poor diet. Thus, dietary changes could help limit the adverse consequences of menopause on women’s health.

Additionally, post-menopausal women consumed more dietary sugars and slept worse than their pre-menopausal counterparts, according to the study. Both of these factors are linked to an increased risk of type 1 and type 2 diabetes, cardiovascular disease and obesity.

Diet and lifestyle changes

Kate Bermingham, first author of the paper from King’s College London, adds: “ZOE’s PREDICT study gives us the opportunity to study the nutrition and health of thousands of people on an unprecedented scale, breadth and depth.

“Our insights are helping to unravel the complex links between lifestyle, hormones, metabolism and health in a way that was simply not possible before. Small changes in diet and lifestyle have the potential to make a big difference in how women manage their symptoms and improve this transition.

According to ZOE, research suggests that there is a need for more personalized nutritional and lifestyle advice for women at different stages of life, which takes into account their individual metabolic responses, hormonal status and microbiome in evolution.

Dr. Berry concludes: “The good news is that what you eat can partially reduce the adverse health effects of menopause, either directly by reducing inflammation and blood sugar spikes, or indirectly by altering the microbiome to a more favorable composition.

“ZOE’s personalized nutrition program promotes healthy gut microbiota and targets diet-induced inflammation, postprandial responses and body weight. We are committed to continuing to integrate our scientific knowledge of menopause into our program to better support women through menopause.

Source: The Lancet

Published online: https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4051462

“Menopause is associated with postprandial metabolism, metabolic health and lifestyle: the ZOE PREDICT study”

Authors: Kate Bermingham et al.